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(2016) found that fasting serum TMAO levels correlated positively with carotid intima-media thickness (cIMT) independently of established CVD risk markers such as insulin resistance, fatty liver, and visceral obesity

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In human case reports, exposure to SGLT2 inhibitors was associated with a higher than expected incidence of congenital malformations, such as hydrocephalus, encephalocele, renal aplasia and esophageal atresia, as well as miscarriages

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doi: 10.1016/j.physbeh.2010.02.029

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