Consequently, further clinical studies are required to evaluate the safety, tolerability, and efficacy of mazdutide in adolescents with obesity before its clinical application in this population can be considered
In addition, urine samples were obtained, and the participants filled out drug effect questionnaires (DEQ)
At this time, fetal infusions of two isotopomers of phenylalanine, Phe ring 2,3,3,2 H 8 (m+8) and Phe ring 2 H 5 (m+5) were started 6 hours apart, both at a rate of 2 ml h 1 , to measure fractional muscle protein synthetic rates as previously described (Rozance et al., 2018)
GL and ADT developed the selection criteria and assessed the risk of bias in included studies
It is possible that participants in the group with neither weight loss nor glucose reduction discontinued or only sporadically used the drug, so we focused on those who achieved a reduction in either outcome, as it is more likely that these individuals used the drug as prescribed
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