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The CDC estimates that around 7,000 babies are born with either a cleft lip or a cleft palate each year in the U.S

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53:300-306 [PMC free article: PMC12420935] [PubMed: 40814081] 366

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Raun and colleagues characterised it as the first selective growth hormone secretagogue: it released GH from rat pituitary cells with potency and efficacy similar to GHRP-6, but unlike GHRP-6 and GHRP-2, both of which raised ACTH and cortisol ipamorelin did not release ACTH or cortisol at levels significantly different from GHRH stimulation, even at doses more than 200-fold above its ED50 for GH release [7]