Collagena protein requiring enzymatic breakdownadds to the protein load your digestive system processes
A vial stored at the wrong temperature, exposed to light, or reconstituted with the wrong water can lose a significant percentage of its activity before the first dose is drawn

Suitable candidates include: Patients with type 2 diabetes and a BMI of 35 kg/m or higher (or 32.5 kg/m or higher for people of South Asian or other minority ethnic backgrounds), or where weight loss would benefit other significant obesity-related comorbidities Those with type 2 diabetes who have not achieved target HbA1c levels with metformin and other oral medications People for whom weight loss would benefit other obesity-related comorbidities or where weight-neutral treatment options are preferred Individuals with occupational implications where insulin therapy would be problematic Importantly, NICE recommends continuing GLP-1 receptor agonist treatment only if there is a beneficial metabolic response: after 6 months, treatment should continue only if HbA1c has decreased by at least 11 mmol/mol (1.0%) and weight has decreased by at least 3% from initial body weight

The nodes on this chip, it says, are the equivalent of 0.7nm nodes, taking chips past nanotech and into angstromtech (to possibly coin a phrase)
Ruegeria pomeroyi works in a similar fashion, with both bacteria oxidizing TMA and later metabolizing TMAO for energy
Or what if genetic variations cause your enzymes to work slowly