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Research indicates that lactate enhances IL-17 production through lactate-dependent metabolic pathways in CD4 + T cells, involving the activation of PKM2 and STAT3, which together facilitate Th17 differentiation and functionality

Previous studies have also demonstrated that GLP-1R agonists exendin-4 (Ex4) induced diuresis and natriuresis by increasing GFR and inhibiting the main renal proximal tubule sodium reabsorption in normotensive rats (101, 102)

Diabetes Metab Syndr Obes 16:24332446 Volpe S, Lisco G, Fanelli M, Racaniello D, Colaianni V, Lavarra V et al (2023) Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: a 26-week prospective real-life study

These are topline figures from Eli Lilly, not yet the full published data

PLoS One 9 (6), e98135

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