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Zhao P, Zhang J, Yin XG, Maharaj P, Narraindoo S, Cui LQ, et al

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NG2-glia in the perivascular space can themselves damage the BBB by disrupting astrocyte end-feet and the tight junction integrity of endothelial cells, leading to altered vascular permeability and related central nervous system inflammation [67]

Going straight to Dihexa for cognitive complaints skips the workup that would identify treatable causes