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Ferroptosis and Cancer Genes RAS The RAS family of small GTPase, including HRAS, NRAS, and KRAS, is closely related to ferroptosis since the two most well-known ferroptosis inducers, erastin (eradicator of RAS and ST) and RSL3 (RAS-selective Lethal 3), are technically oncogenic RAS-selective lethal small molecules (Yagoda et al., 2007

Fitzcharles-Bowe et al, 2007)

They may support recovery by signaling repair pathways, but much of the evidence is still preclinical, so benefits are best described as supportive rather than proven

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A series of secondary injury cascades, such as the release of blood metabolites, microglial activation, thrombin activity, the release of excitatory amino acids, and proinflammatory factors, are initiated (Figure 1)

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