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Crucially, pair-feeding and semaglutide produced virtually identical effects on muscle, showing that muscle loss was driven by reduced calorie intake and not by anything specific to GLP-1 signaling
Journal of Affective Disorders , 322, 1-9
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It was observed that the glycated hemoglobin was significantly reduced in patients who were treated with Tirzepatide compared to Semaglutide in a dose-dependent manner: The HbA1C reduced at week 40 from the baseline by 2.01%, 2.24%, and 2.30% with Tirzepatide 5 mg, 10 mg, and 15 mg compared to Semaglutide 1 mg weekly (1.86%) A greater percentage of the patients in the Tirzepatide groups achieved the target HbA1C at week 40 compared to Semaglutide