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References An J, et al

Researchers originally derived the compound from a fragment of a protective protein found in gastric juice

Pharmaceutics Biopharmaceutics 141 , 111 (2019)

Cancers (Basel) 5, 11631176

Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery