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The available data from clinical trials and post-marketing surveillance have not indicated a direct link between semaglutide use and the development of hypothyroidism

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Cost and Access GLP-1s like Wegovy and Ozempic are expensive and not covered for mental health purposes by most insurers

But as a structural matter, the 503B framework provides more strong quality assurance, and for a product category as safety-critical as sterile injectable medications, that structural advantage matters

Head-to-Head Trial Results The most compelling evidence comes from direct comparison trials where both medications competed under identical conditions

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