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In conclusion, non-pharmacological therapies that focus on controlling the etiology of liver disease, improving nutrition, increasing muscle mass, mitigating triggers and risk factors, and enhancing coping mechanisms are significantly more effective in combating fatigue in cirrhosis compared to pharmacological treatments (Figure 2) (4, 9)

ZIP8 functions as a metal ion transporter crucial to the ferroptosis-driven degeneration of RPECs

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~ When mitochondria arent functioning optimally, they can create a lot of oxidative stress leading to overall elevated inflammatory cytokine production