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Ongoing drug trials are seeking to demonstrate, in the next several years, if GLP-1 drugs are effective at treating and/or reducing rates of obstructive sleep apnea, heart failure, NASH (nonalcoholic steatohepatitis) and MASH (metabolic dysfunction-associated steatohepatitis), chronic kidney disease, peripheral arterial disease, joint replacement, osteoarthritis, Alzheimers, cancer and all-cause mortality

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For example, in a three-month study with a daily intake of 1500 mg of berberine in type 2 diabetes patients, there was a 73 percent reduction in the HOMA index which is a measure of the body's insulin resistance

The downstream medical savings tied to those outcomes rarely appear in the first few months of treatment

Pastorello EA, Incorvaia C, & Ortolani C (1995) The mouth and pharynx