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No reliable human safety profile has been established through controlled clinical development

S100 plays a role in dealing with oxidative stress hence this increase is perhaps indicative of increased oxidative stress (Hu and Lin, 2021)

DSIP is studied in sleep-wake and stress-response pathway models

GIP is a second hormone that enhances glucose-dependent insulin secretion and influences satiety signaling

(PubMed) Rossetti L, Iester M, Tranchina L, et al

Aquat Toxicol 9:91103 Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR, Nichols JW, Russom CL, Schmieder PK, Serrano JA, Tietge JE, Villeneuve DL (2010) Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment