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Understanding Histamine and Its Role in the Body Histamine is a naturally occurring chemical that communicates with various bodily systems

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Most effective clinical options include: Hydroquinone (4%) remains the gold standard to treat hyperpigmentation Q-switched lasers break down melanin deposits effectively Chemical peels with specific acids remove pigmented layers Newer treatments like tranexamic acid and cysteamine cream have fewer side effects Can home remedies really reduce melanin levels

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5.2 Phenols Pterostilbene (PTE), a metabolite with antioxidant, anti-inflammatory, antimicrobial, and anti-neuroinflammatory bioactivities, is primarily derived from Pterocarpus plants and fruits such as blueberries and grapes (Kim et al., 2020)

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