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Both compounds show comparable gastrointestinal tolerability profiles, but Tirzepatide's dual mechanism appears to provide synergistic metabolic benefits through simultaneous activation of glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 pathways

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Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus

LEADER (liraglutide) [44], SUSTAIN-6 (semaglutide) [67], and REWIND (dulaglutide) [70] study showed beneficial renal outcomes, mainly reducing the occurrence of proteinuria

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