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Many people experience issues like nausea, diarrhea, constipation, belching, or general stomach discomfort, especially when first starting the medication or after a dose increase

Overall, Tirzepatide currently outperforms Mazdutide in both weight loss and blood sugar control, making it a compelling choice for patients

Cholestyramine may help symptoms of diarrhea alone

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Interactions Some drugs can also interact with Trulicity, including: Insulin Sulfonylureas (these can cause blood sugar levels to drop dangerously low when combined with Trulicity) Some birth control pills Other GLP-1 or GLP-1/GIP receptor agonist medications such as liraglutide or tirzepatide You should not drink alcohol while taking this drug because alcohol can lower blood sugar