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Prospective studies have highlighted that patients with diabetes who have depression often exhibit more severe and chronic depressive symptoms, which further complicates their dietary habits and metabolic health over time [14]

Tens of thousands of gastrointestinal-related adverse events have been reported to the U.S

Some studies have found participants receiving the high-dose B vitamins had a greater risk of heart attack, stroke and death, compared to those receiving a placebo

Red flags requiring prompt evaluation include heavy or irregular bleeding, pelvic pain, galactorrhea, signs of androgen excess, or missed periods with negative pregnancy tests

doi: 10.1136/jnnp-2017-316011 126 YongHYFYongVW

These treatments also lower homocysteine levels, supporting heart and brain health