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Fig.4 Efficacy evaluation of semaglutide and tirzepatide in HFD+CCl 4 -Induced MASH Mouse Models A

The dura mater was distended, and no obvious cerebrospinal fluid leakage was observed (Fig

19 Gene expression differences involved in O-GlcNAcylation and hexosamine biosynthesis pathway have also been detected between diabetic and nondiabetic individuals, 20 probably because multiple molecules in insulin signaling pathways can be modified by glycosylation which in turn reduces phosphorylation, leading to inhibition of insulin signaling

That makes it more versatile but also explains its broader side-effect profile

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