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31 The overall TRIUMPH1 and TRIUMPH2 sample sizes provide at least 90% power to detect clinically meaningful weight reduction with retatrutide at 9 and 12 mg doses versus placebo on percent change in body weight, assuming each dose is analysed separately in parallel using a 2sample t test at a 2sided significance level of 0.0125

Retatrutide is a once-weekly injection with an approximately 6-day half-life, meaning the time of day within a weekly cycle has minimal pharmacokinetic impact