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Helena Colom, [email protected] This article was submitted to Pharmaceutical Medicine and Outcomes Research, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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While polymorphisms in UGT , CYP , SULT and GST genes are well established [22,23,8992] and might affect the response to acetaminophen, only polymorphisms in UGT genes have been widely studied in relation to APAP pharmacokinetics in humans [20,23,26,93]

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Late-onset N -acetylglutamate synthase deficiency: report of a paradigmatic adult case presenting with headaches and review of the literature