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Factors to Consider When Choosing Between Them Purity and Consistency: Ozempic, an FDA-approved medication, ensures consistent dosage and purity due to strict manufacturing controls

10 Many misrepresent the naturally occurring GLP-1 hormone with GLP-1 RA

No significant differences in secondary outcomes were observed post-weighting, and all results were consistent across multiple sensitivity analyses

Conditions that need clinician oversight Personal or family history of medullary thyroid carcinoma or MEN 2

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Health technology assessment bodies require demonstration of value beyond statistical efficacy, including durability of effect, quality-of-life improvement, and reduction in downstream healthcare costs