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This less conserved domain, compared to the N-terminal domain, notably contains a well-conserved N-capping box (S/TXXD) including the S/T N-cap residue (Figure 3A) and a hydrophobic staple motif located at the N-terminal part of 6 helix

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In parallel, an increase in NAMPT activity boosts autophagy, 86,89 while a decrease in OCT4 enhances autophagy inhibition