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The greater decrease in LAC levels in severe forms of MDD and in patients with treatment resistant depression (TRD) is akin to a kindling-like progression of depression in that earlier age at onset and/or the presence of early life adversity, such as emotional trauma, conveys liability to more severe and treatment-resistant course of illness [51, 53, 55]
(1997) IGFBP-3 Interacts with the Type 1 IGF Receptor, Reducing Receptor Affinity PubMed ID: 9389554 Coleman ME et al
A 2013 test tube study suggests that the MCT oil may have more potent effects on seizure control than a widespread anti-epileptic drug
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