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The Plavix cliff also illustrated the paragraph IV lottery dynamic: generic companies that successfully challenge a patent before expiry can be rewarded with 180-day exclusivity the period during which only they and the innovator (via AG) can sell the drug

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The drug has anti-inflammatory effects, they said, and it also appears to reverse some of the changes in airways and the "hyper-responsiveness" of airways that asthma brings

Factors like temperature and physical activity can alter this

Android fat, the dangerous visceral fat that surrounds organs and drives metabolic disease, decreased by up to 31.4% at the 12mg dose

But drug manufacturers do not have much incentive to make such a deal because demand is already enormous for GLP-1s, Klebanoff said