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By modulating systemic metabolic homeostasis, the liver acts as a key intermediary in the progression of metabolic syndrome and its neurological complications

In a phase II trial, adults with a BMI of 30 or 27 kg/m with comorbidities were randomized to receive efpeglenatide at doses of 4 mg weekly, 6 mg weekly, 6 mg biweekly, or 8 mg biweekly, or a placebo, all combined with a hypocaloric diet [17]

& Chazenbalk, G