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This structural feature is one reason why cinnamic acids exhibit stronger antioxidant activity than their corresponding benzoic acids

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In line with these observations, the treatment of the murine syngeneic PCa and bladder cancer models with the JHU-083 inhibitor led to the reprogramming of the tumor-associated macrophages (TAMs) from an immunosuppressive to inflammatory state and increased TAM proliferation and glycolysis [99]

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Estimates suggest oral bioavailability for peptides like BPC-157 may be only 1-2%, meaning massive doses would be required to achieve systemic effects

In clinical settings, GHK-Cu formulations are used in dermatologic and aesthetic surgery to optimize post-procedure healing