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Research protocols often recommend refrigeration after reconstitution and limited use windows (e.g., 728 days depending on the compound)

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Classical RAAS cascade gives rise to the production of angiotensin II (Ang II) which binds to the Ang II type 1 receptor leads to vasoconstriction, cell proliferation, inflammation, increased oxidative stress and cell apoptosis [44]

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Notably, Akt inhibition caused a more pronounced reduction in both total GLUD1 protein levels and R76 methylation than PI3K inhibition, suggesting that Akt may more directly regulate GLUD1 methylation (Fig