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Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]
Moreover, while MT typically regulates survival signaling and tumor progression through its G protein-coupled membrane receptors, MTNR1A and MTNR1B [4], our findings suggest a receptor-specific effect
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