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Cullin-RING ubiquitin ligase regulatory circuits: a quarter century beyond the f-box hypothesis

Damage and error theory, in contrast to the planned explanation of ageing, emphasises the effect of external variables on an individual, which eventually leads to a cumulative negative effect on the body

It is indicated as an adjunct to a reduced-calorie diet and increased physical activity

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Dose may be increased to 14 mg once daily if additional glycemic control is needed after at least 30 days on the 7 mg dose