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The defining structural feature is a 23-membered side-chain lactam bridge

Corrination of a GLP-1 receptor agonist for glycemic control without emesis

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Semaglutide does not directly cause depression in most users

Gastrointestinal effects represent the most common concern: Nausea and vomiting : May be pronounced when initiating either medication or during Wegovy dose escalation Diarrhoea or constipation : Both medications can affect bowel habits Reduced appetite : Wegovy's appetite-suppressing effects combined with SSRI-related nausea may significantly reduce food intake Abdominal discomfort : Bloating, dyspepsia, or gastric pain may occur To minimise gastrointestinal distress, consider taking escitalopram with food and following the gradual Wegovy dose escalation schedule precisely

Jin Q, Cirelli JA, Park CH, et al