L-Arginine and L-Citrulline have documented interaction profiles with nitrate medications, antihypertensive drugs, and PDE5 inhibitors
M., Satylganova, A., & Lau, D
These mechanisms further activate the hypothalamic-pituitary-adrenal axis, hepatic glycogenolysis, hyperglycemia, hyperlipidemia, and insulin resistance, contributing to core depressive features of anhedonia, emotional dysregulation, and cognitive slowing ( The complex etiopathogenesis of T2DM has been explored in detail and includes insulin resistance (in the liver, muscles, and adipose tissue), impaired insulin secretion, -cell dysfunction, immune dysregulation and meta-inflammation, hyperglucagonemia, disrupted gut microbiota, increased gastric glucose absorption, renal adaptation with enhanced glucose reabsorption and gluconeogenesis, decreased dopamine, and heightened sympathetic tone in the brain ( via cells of the circumventricular organs located around the third and fourth brain ventricles, transmitting signals to deeper brain structures
2006, van den Hoek, Heijboer et al
May-Jun 2016;18(3):357-63
In addition to its high antioxidant capacity, it has the characteristic that it is able to increase and enhance the function of other antioxidants such as vitamin E, vitamin C
