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Starting at a low dose and gradually titrating upwards helps minimise these effects

For decades, Metformin has been the bona-fide, first-line treatment for patients with type 2 diabetes: not only is it available in a convenient, daily tablet, but its also among the most well tolerated medications of its type, with little incidence of adverse side effects and very minor common side effects

Its smaller molecular structure allows efficient diffusion in tissue models, facilitating localized cellular interactions

doi: 10.1159/000313377 37 ButlerMGTheodoroMSkouseJD

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Cipriani A, Barbui C