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Creatine supplementation may modestly increase measured serum creatinine levels, which can confound creatinine-based estimated glomerular filtration rate (eGFR) calculations

Another potential mechanism for age-dependent loss of antioxidant genes was provided by one of the studies showing that the presence of transcription repressor BACH1 along with the absence of coactivator CREB-binding protein (CBP) in the aged mice may convert NRF2 binding from an active ARE to an alternative ARE [114]

Nature Metabolism , 5 (9), 15441562

173 However, it is important to note at least two studies have found no relationship between folate intake, blood folate levels, MTHFR mutations, and assisted reproductive outcomes