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If the dysesthesia rates are higher in the broader TRIUMPH population than in TRIUMPH-4, the FDA may request additional safety studies

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Advanced / Aggressive Protocol (2 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)

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This selective action may explain why they could potentially reduce drug-seeking behaviors without broadly suppressing normal motivation, although this remains to be confirmed in humans