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Meydani SN, Sastre J, et al (1994)

The liver is its primary site of manufacturing

Values are shown as percentage of the predicted value

The immune response commences early during penetration in the epidermis, with HLA-DR+ cells, likely Langerhans cells, having been shown to aggregate at the sight of infection within 48 h, while keratinocytes respond to penetration by the release of the proinflammatory cytokines IL-1 and IL-1 (77, 95)