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In the STEP 1 trial extension, 327 participants who had been on semaglutide 2.4 mg weekly were tracked for one year after stopping

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Constipation appears more frequently than diarrhea, affecting roughly 20% of treatment participants, while true vomiting occurs in fewer than 5% when doses are titrated slowly

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PMC Ipamorelin raised GH without elevating cortisol or ACTHkey for preserving muscle while avoiding stress-hormone spikes