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After 12 h, cells were washed with D-PBS to remove the complete medium and loaded with 40 L of 10 M coelenterazine 400a (Maokangbio) diluted in the assay buffer (HBSS containing 0.01% bovine serum albumin and 5 mM HEPES, pH 7.5) per well

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Free radicals are highly reactive molecules produced by environmental factors or normal metabolism that can damage skin cells and tissues and lead to oxidative stress

It has been under research for over 50 years, with consistent findings of excellent tolerability in both topical and injectable applications

T.et al (2020)

In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]