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Improved Training Capacity Better recovery may allow people to perform more intense workouts, potentially leading to changes in body composition

In addition to inhibiting the expression of COX-2 in lung cancer cells, IGFBP-4 also inhibited the proliferation, migration and metastasis of cancer cells through the modulation of the PI3K/AKT, ERK and CREB pathways, which highlights the anticancer value of IGFBP-4 (111)

In light of its role in the bi-directional transfer of information between the periphery and the brain, the PNS is well positioned to control energy metabolism, not only by modulating glycaemia via regulation of sympathetic outflow to the skeletal muscle 32 , but also by promoting GIP-induced vasodilation in the mesenteric vasculature, including the adipose tissue 33,34