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Reduced L-glutathione (GSH) is the preferred form for oral supplementation

Besides, the effects of berberine in Alzheimers mice may be related to the inhibition of NF-B activity and lipid peroxidation, and the increase of glutathione activity in the hippocampus (Figure 2)

10.1124/jpet.110.177287 92 ObaraI.GouldingS

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Regarding tolerability and post treatment side effects in two groups, only one patient in the first group developed mild erythema on right side, which subsided within few hours without any treatment