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[2] Additionally, findings from SURPASS-1 and SURPASS-2 highlight the importance of gradual dose increases to improve patient adherence and reduce dropouts

Joshua Silva, MD Nov 7, 2025 13 min read Updated: Apr 17 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As GLP-1 and GLP-1/GIP medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) continue to transform medical weight management, one question comes up repeatedly: Do these medications cause muscle lossor even muscle wasting

doi: 10.11909/j.issn.1671-5411.2015.04.013 73 YangJWangZZhangX

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This is not ordinary tiredness, but a profound weakness that persists despite adequate rest

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