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Conversely, other food or food-derived molecules reinforce TJ integrity while exerting antioxidant effects, thereby offering potential therapeutic benefits for conditions characterized by increased intestinal permeability including inflammatory bowel disease, sepsis, and coeliac disease

Since PE-22-28 is a synthetic analog, it is hypothesized that it may carry similar or potentially more pronounced interactions with BDNF-related pathways, though direct evidence remains limited

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