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These findings represent substantial improvements over traditional anti-obesity medications and approach the efficacy levels historically associated with bariatric surgery

doi: 10.1016/j.chest.2025.03.030 52

This might suggest that tirzepatide affects the gut microbiota [81]

Liang Y, et al

In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

It should be noted that, while the tolerability and efficacy profile of the GLP-1R agonist/GIPR antagonizing antibody maridebart cafraglutide warrants enthusiasm, it has not yet been directly compared to GLP-1R agonism or dual GLP-1R/GIPR agonism in the clinical setting