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In the STEP 1 trial which studied semaglutide in adults with overweight or obesity, researchers studied body mass composition as a secondary endpoint via DXA in a subpopulation of trial enrollees randomized to treatment or placebo

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Chemical synthesis allows for the incorporation of non-natural amino acids and modifications (e.g., PEGylation, lipidation), offering greater design flexibility

The company says it is planning to initiate a Phase III development program with amycretin for adults with overweight or obesity during the first quarter of 2026

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