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In Canada, the relevant patent lapsed earlier this year generic versions became technically legal as of January 2026 and Health Canada took roughly four months from that point to clear the first submission

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Give dexamethasone or budesonide to mice, and ileal proglucagon mRNA falls and glucose-stimulated GLP-1 secretion drops ( Sato et al., 2015 )

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In addition to technical challenges, clinical adoption depends on careful planning, comprehensive training, and the thoughtful use of explainable AI strategies to enhance transparency and clinician engagement