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People who regularly consume creatine find they store more water in their muscles, provided they are hydrating adequately. It is this osmotic attribute of creatine, though, that can lead to gastrointestinal distress

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Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines

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