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Acknowledgments The authors would like to express their sincere gratitude to Hao Wang, Cankun Zhou, Yonglian Chen, Jun Lyu, Minqing Feng, and Xiaobin Huang for their valuable contributions to the early stages of this work and for their collaborative support throughout the research process

Animals Adult male (n=68) and female (n=68) SpragueDawley rats were bred in house from breeding pairs obtained from Charles River, Quebec, Canada, after weaning rats were double-housed in a 12-h light/dark cycle

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10.1111/acn.12016 406 SorboniS

This results in endocytic uptake of TJ components and provides infectious agents with an opportunity to enter systemic circulation (Roxas and Viswanathan 2018)