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RF is a prevalent feature observed in renal injury and the decline of renal function caused by various etiologies, serving as a common pathway for the progression of diverse chronic kidney diseases (Boor and Floege, 2012

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The depletion of ER Ca 2+ promotes the formation of mitochondrial-associated ER membrane, leading to mitochondrial Ca 2+ overload and dysfunction

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Although US in a non-invasive and practical method, it has low sensitivity for mild levels of steatosis and cannot be used for the distinction between NAFLD and NASH, without a concomitant liver biopsy

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