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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]

So vitamin deficiencies are common

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Brain Res Rev 25:335-358 Riddle DR (2007) Brain Aging: Models, Methods, and Mechanisms

For those seeking holistic weight loss , recognizing the role of the gut-brain axis is crucial