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Large cardiovascular outcome trials involving tens of thousands of patientssuch as LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide)have not demonstrated an increased incidence of medullary thyroid carcinoma or other thyroid malignancies compared to placebo groups

As a result, additional prospective and controlled studies are needed before definitive conclusions can be drawn

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While data on tirzepatides long-term cardiovascular outcomes is still developing, early evidence points to comparable benefits, making both options valuable for patients looking to manage weight and enhance heart health simultaneously

Oxidative stress is caused by high levels of free radicals