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As a critical intrinsic regulator of neurogenesis in the adult DG of the hippocampus, Prox1 is required for maintenance of intermediate progenitors, maturation of granule neurons in DG, differentiation and maturation of glutamatergic interneurons, as well as specification of DG cell identity over CA3 pyramidal fate [24]

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both of these do, so pairing them does not offset that concern

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